What determines my circadian rhythm?

Discover why some people who seem to jump out of bed in the morning while others struggle to wake up every day.

There are people who seem to jump out of bed in the morning and there are those who struggle to wake up every day. Why is that? The short answer: circadian rhythm.

Everyone has their own circadian rhythm. People’s rhythms differ in two dimensions: One is the period in which it cycles, which in healthy adults is 24:18h +- 12 minutes. [1] The other is the time to which the clock is set which is scientifically called the ‘circadian phase’. The 3 main factors of genetics, age and environment determine the time of your clock. You can actively influence this by adjusting your environment accordingly.

Genetic disposition

In 2017, the Nobel Prize in Medicine was awarded to three researchers for their discoveries of the molecular mechanisms that control the circadian rhythm. [2] It is the oscillating gene expression in certain proteins throughout the day and their degradation overnight that manifests itself in the circadian rhythm we observe. [3]

An estimated 40% of the population tends to get up earlier (‘larks’), while about 30% would naturally get up later (‘owls’). [4] The tendencies towards morning fitness, normal type or evening fitness are distributed in an almost Gaussian curve.

Distribution of larks and owls showing that moderately early chronotypes prevail.

Age

The circadian rhythm changes with age. In adolescence, it experiences a peak delay of 1-3 hours, which means that teenagers and young adults are typically late risers. [5] Towards later life, the circadian clock advances, which is why many older people wake up early in the morning. [6] In addition, the circadian rhythm attenuates overall with age. Therefore, a rhythmic lifestyle (e.g. fixed meal times or times of light exposure) can be of great benefit to the well-being of older people. [7]

Centre of sleep on days off (MSF, used as an approximation for chronotype) over age. From [11]

External timers

To avoid drifting from the actual time of day, your circadian clock synchronises to various stimuli that serve as indicators of the time of day. These stimuli, scientifically called zeitgebers (after which this website is named), cause your internal clock to delay or advance depending on the timing of the stimulus. [4] Light is considered the most important zeitgeber, but other stimuli such as food intake or physical activity can also influence your internal clock. [8,9,10] If you know how different zeitgebers influence your circadian rhythm, you can organise your lifestyle so that your internal clock is in harmony with your external schedule.

References

[1] Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., … Kronauer, R. E. (1999). Stability, precision, and near-24-hour period of the human circadian pacemaker. Science284(5423), 2177–2181. https://doi.org/10.1126/science.284.5423.2177

[2] https://www.nobelprize.org/prizes/medicine/2017/press-release/

[3] Andreani, T. S., Itoh, T. Q., Yildirim, E., Hwangbo, D. S., & Allada, R. (2015, December 1). Genetics of circadian rhythms. Sleep Medicine Clinics. W.B. Saunders. https://doi.org/10.1016/j.jsmc.2015.08.007

[4] Walker, M. (2017). Why we sleep: Unlocking the power of sleep and dreams. Simon and Schuster.

[5] Hagenauer, M. H., Perryman, J. I., Lee, T. M., & Carskadon, M. A. (2009, June). Adolescent changes in the homeostatic and circadian regulation of sleep. Developmental Neuroscience. Dev Neurosci. https://doi.org/10.1159/000216538

[6] Duffy, J. F., Zitting, K. M., & Chinoy, E. D. (2015, December 1). Aging and circadian rhythms. Sleep Medicine Clinics. W.B. Saunders. https://doi.org/10.1016/j.jsmc.2015.08.002

[7] Manoogian, E. N. C., & Panda, S. (2017, October 1). Circadian rhythms, time-restricted feeding, and healthy aging. Ageing Research Reviews. Elsevier Ireland Ltd. https://doi.org/10.1016/j.arr.2016.12.006

[8] Blume, C., Garbazza, C., & Spitschan, M. (2019, September 1). Effects of light on human circadian rhythms, sleep and mood. Somnologie. Dr. Dietrich Steinkopff Verlag GmbH and Co. KG. https://doi.org/10.1007/s11818-019-00215-x

[9] Lewis, P., Oster, H., Korf, H. W., Foster, R. G., & Erren, T. C. (2020, April 1). Food as a circadian time cue — evidence from human studies. Nature Reviews Endocrinology. Nature Research. https://doi.org/10.1038/s41574-020-0318-z

[10] Yamanaka, Y., Honma, K. I., Hashimoto, S., Takasu, N., Miyazaki, T., & Honma, S. (2006). Effects of physical exercise on human circadian rhythms. In Sleep and Biological Rhythms (Vol. 4, pp. 199–206). Springer. https://doi.org/10.1111/j.1479-8425.2006.00234.x

[11] Roenneberg, T., Kuehnle, T., Pramstaller, P. P., Ricken, J., Havel, M., Guth, A., & Merrow, M. (2004, December 29). A marker for the end of adolescence. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2004.11.039

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